Jones PH, et al; STELLAR Study Group. Background: Please enable it to take advantage of the complete set of features! 1. A shift in the routine prescribing of statin therapy to every-other-day would have important implications. The primary efficacy outcome was the difference in the mean percentage change in LDL from baseline between rosuvastatin and placebo. Glueck CJ, Aregawi D, Agloria M, Khalil Q, Winiarska M, Munjal J, Gogineni S, Wang P. Clin Ther. Once-a-week rosuvastatin (2.5 to 20 mg) in patients with a previous statin intolerance. Am J Cardiol 2008;101:1747-1748. Two of the 17 patients (11.8%) in the placebo treatment phase and three of the 15 patients (20%) in the rosuvastatin treatment phase experienced myalgias requiring cessation of therapy. 5. Efficacy of rosuvastatin (5 mg and 10 mg) twice a week in patients intolerant to daily statins. Is There a Link Between Miscarriage and Future Cardiovascular Disease? J Clin Lipidol. USA.gov. Take once daily. Periodic rosuvastatin or atorvastatin dosing arrays (PRADA): patient-centered practice. Conclusion: There are exceptions to taking these nutrients so ask your doctor (yes, the same one that gave you the statin.) Be diligent about putting back the nutrients that statins interfere with such as the coenzyme Q10, selenium, and vitamin K2, along with other heart healthy nutrients. Rosuvastatin once a week was tolerated by 37 (74%) of the 50 study participants, with doses ranging from 2.5 mg to 20 mg a week (mean 10 +/- 4 mg). One-year efficacy and safety of rosuvastatin + fenofibric acid combination therapy in patients with mixed dyslipidemia: evaluation of dose response. SLCO1B1 Polymorphisms and Statin-Induced Myopathy. Once-a-week rosuvastatin (2.5 to 20 mg) in patients with a previous statin intolerance. By Harold L. Karpman, MD, FACC, FACP, Clinical Professor of Medicine, UCLA School of Medicine. Two 8-week treatment phases consisted of rosuvastatin 5 mg once-weekly or matching placebo, with a dose titration to 10 mg once-weekly if not at LDL goal at week 4. If you have to take statins, please use the lowest dose possible. May be taken at any time of the day (morning or night); however, it is best to be consistent with the time you take your tablets. doi: 10.1371/currents.eogt.d21e7f0c58463571bb0d9d3a19b82203. ReliasMedia_AR@reliasmedia.com, Do Not Sell My Personal Information  Privacy Policy  Terms of Use  Contact Us  Reprints  Group Sales, For DSR inquiries or complaints, please reach out to Wes Vaux, Data Privacy Officer, DPO@relias.com, Design, CMS, Hosting & Web Development :: ePublishing, New contraceptives widen choices, but the Pill still is a top selection, Statin Use Is Associated With a Lower Risk of Community-acquired. NIH Eur Cardiol. Epub 2008 Feb 19. Clin Ther. The average dosage used was 9.5 mg/week. Methods: You must have JavaScript enabled to enjoy a limited number of articles over the next 360 days. Synopsis: Once-a-week rosuvastatin therapy was well tolerated in patients with a history of adverse events to one or more statins and led to significantly improved lipoprotein changes. Published data have demonstrated that instead of administering rosuvastatin on a daily basis, alternative dosing schedules (every other day, three times a week, and twice a week) for patients with previous adverse events, presumably secondary to statin therapy, have improved patient tolerability and at the same time are capable of significantly lowering total serum cholesterol and low-density lipoprotein cholesterol (LDL-C).1-3 These results were probably possible because of rosuvastatin's long half-life (approximately 19 hours)4 and, because the LDL-C reduction was significant5 in these studies, it has been suggested that rosuvastatin might be an attractive statin agent for a weekly dosing schedule. 5 to 20 mg) in patients with a previous statin intolerance Am J Cardiol, 103 (3) (2009), pp. Am J Cardiovasc Drugs. Alternate day treatment will be less expensive, and non-daily dose of certain statins may reduce the already-low but concerning incidence of musculoskeletal pain and weakness that can be a side effect of statin use. In addition, three patients (20%) were able to attain LDL goal on rosuvastatin compared with zero patients (0%) on placebo. Patients were started on a ro suvastatin dosage that ranged from 2.5 to 20 mg, given as a single, oral dose once a week. Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance. The lipid-lowering effects of once-a-week rosuvastatin proved to be statistically significant; however, no attempt was made to determine whether this alternative dosing regimen was capable of reducing cardiovascular events over the course of this relatively short-term study. Rosuvastatin: A high potency HMG-CoA reductase inhibitor. Once-weekly low-dose rosuvastatin is an effective and well-tolerated lipid-lowering therapy option for patients not at LDL goal and previously unable to tolerate statins because of a history of myalgias. COVID-19 is an emerging, rapidly evolving situation. Once-a-week rosuvastatin (2. 393-394 Article Download PDF View Record in Scopus Google Scholar Curr Atheroscler Rep. 2015;17(2):475. doi: 10.1007/s11883-014-0475-4. Am J Cardiol 2009;103:393-394. 2006 Jun;28(6):933-42. doi: 10.1016/j.clinthera.2006.06.004. Efficacy of Patient Aligned Care Team Pharmacist Services in Reaching Diabetes and Hyperlipidemia Treatment Goals. HHS 2010;10(6):383-400. doi: 10.2165/11204600-000000000-00000. It is important to recognize that the retrospective observational study reported by Ruisinger was performed in a very small group of patients (n = 50) and was not placebo-controlled.  |  Am J Cardiol 2009;103:393-394. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Gadarla M, et al. The specific dosage used for each patient was based primarily on each patient's prior history of statin use and the severity of the adverse events that they developed. Am J Cardiovasc Drugs. 2004 Sep;26(9):1368-87. doi: 10.1016/j.clinthera.2004.09.005. Ann Pharmacother. 393-394 Article Download PDF View Record in Scopus Google Scholar Drugs R D. 2014 Dec;14(4):221-5. doi: 10.1007/s40268-014-0061-9. NLM Backes JM, et al. A new study tracked how they did. Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies. Backes JM, Venero CV, Gibson CA, Ruisinger JF, Howard PA, Thompson PD, Moriarty PM. Ann Pharmacother 2008; 42:341-346. Statin Use and Cognitive Effects: Not a Brain Drain. A prospective trial of once-a-week rosuvastatin dosing in individuals with a history of myalgias on statin therapy achieved a >12% lowering of LDL-C … Dr. Karpman reports no financial relationship to this field of study. PLoS Curr. Statins: Practical Considerations - A Review. Some patients decide to stop taking statins, a cholesterol-lowering drug, if they experience side effects. Lopez LM. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* trial). Epub 2011 Sep 21. 2. Clipboard, Search History, and several other advanced features are temporarily unavailable. Get the latest research from NIH: https://www.nih.gov/coronavirus. The primary efficacy outcome was the difference in the mean percentage change in LDL from baseline between rosuvastatin and placebo. Objective: Non-traditional dosing of statins in statin-intolerant patients-is it worth a try? Source: Ruisinger JF, et al. Results: A significant difference in the mean percentage change in LDL from baseline for rosuvastatin … Rosuvastatin: a review of its use in the prevention of cardiovascular disease in apparently healthy women or men with normal LDL-C levels and elevated hsCRP levels. Am J Cardiol 2007;99:291. 1-800-370-9210 Patients tolerating the once-a-week dosing regimen experienced a 17% reduction in total cholesterol, a 23% reduction in LDL-C, a 12% reduction in triglycerides, and a 5% increase in high-density lipoprotein cholesterol (all significant, P < 0.001) during a mean follow-up period of 4 months. 5 to 20 mg) in patients with a previous statin intolerance Am J Cardiol, 103 (3) (2009), pp. Patients tolerating the once-a-week regimen experienced a 17% reduction in total cholesterol, 23% reduction in low-density lipoprotein cholesterol, 12% reduction in triglycerides, and a 5% increase in high-density lipoprotein … 2014 Dec;9(2):71-75. doi: 10.15420/ecr.2014.9.2.71. 2013 Dec 4;5:ecurrents.eogt.d21e7f0c58463571bb0d9d3a19b82203.  |  Patients with lipid levels measured 1-3 days and 4-7 days after receiving their last rosuvastatin dose had similar mean LDL-C reductions. The once-a-week schedule was tolerated by 74% of the patients with doses ranging from 2.5 to 20 mg once weekly. In this randomized, double-blind, placebo-controlled crossover study we enrolled a total of 17 Clement J. Zablocki Veterans Affairs (VA) primary care patients with a diagnosis of hyperlipidemia and a history of myalgias on statin therapy who were not currently on a statin and not at LDL goal. The dosage of atorvastatin needs to be individualized but initially should start at 10-20 mg/day and be guided by the results of cholesterol …