History. Data to suggest that statins may reduce the severity of COVID-19 or prevent death from it are limited. A. That means blood levels of the medication will be higher than expected. Compounds in grapefruit inhibit an enzyme in the digestive tract that breaks down these medications. Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects. Avoid eating foods that are high in fat or cholesterol. Some statin drugs to lower cholesterol, such as Zocor (simvastatin) and Lipitor (atorvastatin Certain statins (atorvastatin, lovastatin and simvastatin) interact with grapefruit juice. There would be warning signs however as Proton Soup mentioned. Those people, who might already be at their body's limit with a grapefruit, are overdoing it with the statin. For example, a statin used to lower cholesterol called simvastatin created a 330 percent higher systemic concentration of the drug when the patient drank a 200-mL glass of grapefruit … Additionally, one study cited by the authors showed that when simvastatin was taken 24 hours after ingestion of the same large volume (1,200 mL) of grapefruit juice, the effect of grapefruit … There always are unless sudden death really = SUDDEN. The first published clinical report on grapefruit drug interactions was in 1991 in The Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine." Simvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. Grapefruit juice can affect how well some medicines work, and it may cause dangerous side effects. Avoid the use of grapefruit products while taking this medicine.