They work by reducing excess fluid in different parts of the body to lower eye pressure and control seizures and nausea. Drugs & Medications RINATE Pediatric Suspension Zonisamide/Carbonic Anhydrase Inhibitors; Anticholinergics Interactions This information is … Illustrated with numerous X-ray crystallographic structures. Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies Ashok Aspatwar , 1, * Jean-Yves Winum , 2 Fabrizio Carta , 3 Claudiu T. Supuran , 3 Milka Hammaren , 1 Mataleena Parikka , 1, 4 and Seppo Parkkila 1, 5 Carbonic Anhydrase Inhibitors multum therapeutic drug class usage statistics for the United States (2008 - 2018). Statistics include a comparison of all drugs within the multum therapeutic drug class of Carbonic Anhydrase Inhibitors. Dozolamide (Trusopt®, MSD) is the topical carbonic anhydrase inhibitor used most frequently in managing glaucoma in dogs and cats. Carbonic anhydrase inhibitors (CAIs) are extremely useful in reducing intraocular pressure by about 15 mmHg. It has recently emerged that CA inhibitors (CAIs) targeting the mitochondrial isoforms CA VA and VB have potential as novel antiobesity drugs. But recently, it has also emerged that these enzymes have the potential for designing anti-infective drugs (anti-fungal and anti-bacterial agents) with a novel mechanism of action. Carbonic anhydrase inhibitors. Inhibition of the metalloenzyme carbonic anhydrase (CA, EC has pharmacologic applications in the field of antiglaucoma, anticonvulsant, antiobesity, and anticancer agents but is also emerging for designing anti-infectives (antifungal and antibacterial agents) … This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. Inhibition of the metalloenzyme carbonic anhydrase (CA; EC has pharmacologic applications in the field of anti-glaucoma, anti-convulsant and anti-cancer agents. Carbonic anhydrases (CAs, EC are ubiquitous metalloenzymes in mammals, being involved in numerous biosynthetic processes, including gluconeogenesis, lipogenesis and ureagenesis. They reduce aqueous production by inhibition of carbonic anhydrase. Recent Developments of Carbonic Anhydrase Inhibitors as Potential Drugs Jamshed Iqbal , 1 Mariya Al-Rashida , 2 Serdar Durdagi , 3 Vincenzo Alterio , 4 and Anna Di Fiore 4 1 Department of Pharmaceutical Sciences and Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad, Pakistan Carbonic anhydrase inhibitors are used to treat glaucoma, altitude sickness, edema, and epilepsy. Carbonic Anhydrase Inhibitors.